Leukocyte labeling with 51-chromium. II. Leukocyte kinetics in chronic myelocytic leukemia.

Sequential or simultaneous leukocyte kinetic studies using radioactive diisopropylfluorophosphate and radiochromate (31Cr) yielded similar or identical blood leukocyte disappearance curves in seven patients with chronic myelocytic leukemia (CML). Body surface counting regularly showed a rise in the spleen counting rate during the first hours after infusions of granulocyte populations of mixed maturity. Epinephrine-induced leukocytosis was associated with a fall in the spleen counting rate, lesser decreases over the liver and marrow, rises in the heart and lung counting rates, and an unchanged blood leukocyte disappearance curve. These changes are consistent with the mobilization by epinephrine of a marginal